Efficacy and Metabolism of Azonafide Antibody-Drug Conjugates in Microgravity (ADCs in Microgravity): The crew retrieved a BioCell Habitat, inoculation kits and ADC samples from a Minus Eighty Degree Celsius Laboratory Freezer for ISS (MELFI), set up hardware inside the Microgravity Science Glovebox (MSG) Work Volume and inoculated the Multiwall BioCells using Inoculum syringes. Later today the crew will repeat these steps with a second BioCell Habitat which begins an 11-day run. The ADCs in Microgravity investigation evaluates new antibody-drug conjugates that combine an immune-activating drug with antibodies to target only cancer cells, increasing the effectiveness of chemotherapy and reducing its side effects. In microgravity, cancer cells grow in three-dimensional, spheroid structures that closely resemble their form in the human body, allowing for better drug testing. This investigation may accelerate development of targeted therapies for cancer patients. NeuroMapping: The crew set up the Neuromapping hardware and performed tests in “strapped in” and “free floating” body configurations. During the test, the crew executed three Behavioral Assessments: mental rotation, sensorimotor adaptation, and motor-cognitive dual tasking. The investigation studies whether long-duration spaceflight causes changes to brain structure and function, motor control, or multi-tasking abilities. It also measures how long it would take for the brain and body to recover from possible changes. Previous research and anecdotal evidence from astronauts suggests movement control and cognition can be affected in microgravity. The NeuroMapping investigation performs structural and functional magnetic resonance brain imaging (MRI and fMRI) to assess any changes that occur after spending months on the ISS. Food Acceptability: The crew completed a Food Acceptability questionnaire. The Food Acceptability investigation seeks to determine the impact on food acceptability on ISS of repetitive consumption of food currently available from the spaceflight food system. Results will be used in developing strategies to improve food system composition to support crew health and performance on long duration missions. Fine Motor Skills (FMS): The crew completed a series of interactive tasks during a FMS session. The investigation studies how the fine motor skills are effected by long-term microgravity exposure, different phases of microgravity adaptation, and sensorimotor recovery after returning to Earth gravity. The goal of the investigation is to determine how fine motor performance in microgravity varies over the duration of six-month and year-long space missions; how fine motor performance on orbit compares with that of a closely matched participant on Earth; and how performance varies before and after gravitational transitions, including periods of early flight adaptation and very early/near immediate post-flight periods. JEM Wireless Access Point (J-WAP)-2 Install: The crew removed the JEM Wireless Access Port located at the JPM1A7 location and replaced it with an improved JEM Wireless Access Port (J-WAP)-2. JWAP-2 will provide JEM internal Wi-Fi capability which incorporates new radio communications standards. Today’s Planned Activities All activities were completed unless otherwise noted. Antibody Conjugates MELFI Sample Retrieve Combustion Integrated Rack Alignment Guide Removal Fine Motor Skills Experiment Test – Subject Ultrasound 2 HRF Rack 1 Power On Health Maintenance System (HMS) Ultrasound 2 Scan Antibody Conjugates Thawing and Inoculation Preparation Health Maintenance System (HMS) Ultrasound 2 Post Exam Ultrasound 2 Guided Data Export JEM Wireless Access Point 2 Installation Antibody Conjugates MELFI Sample Retrieve Antibody Conjugates Biocells Inoculation Antibody Conjugates MELFI Sample Retrieve Antibody Conjugates Biocells Inoculation Antibody Conjugates MELFI Sample Retrieve Antibody Conjugates Biocells Inoculation Antibody Conjugates MELFI Sample Retrieve Antibody Conjugates Biocells Inoculation Food Acceptability Questionnaire – Subject Antibody Conjugates Session Cleanup Cupola Window #2 Shutter Closed БД-2 Physical Fitness Evaluation (on БД-2) Health Maintenance System (HMS) OCT Setup NeuroMapping Experiment Neurocognitive Test – Subject Preventive maintenance of DC1 АСП hatch sealing mechanisms and Progress 435 (DC1) [АСА] hatch Health Maintenance System (HMS) – OCT Exam Removal of ССД305 Light Units from Progress 435 (DC1) and Stowage in Spares Kit. (Stow in МИМ1_ПБ_407_1, CTB No.4355 (00180358J)) Antibody Conjugates MELFI Sample Retrieve Progress 435 Activation, Air Duct Removal Countermeasures System (CMS) Heart Rate Monitor (HRM) iPad Downlink Health Maintenance System (HMS) – OCT Exam Connecting HDV Sony HVR-Z7E Camcorder in DC1 and starting NASA MPEG-2 application (for TV coverage of Removal of Quick Release Screw Clamps (ЗВБ)) On MCC Go Removal of quick-release screw clamps from DC1-Progress 435 side Video of the interface Antibody Conjugates Thawing and Inoculation Preparation Health Maintenance System (HMS) OCT Stow DC1-Progress Hatch Closure Antibody Conjugates MELFI Sample Retrieve Antibody Conjugates Biocells Inoculation DC1-СУ and Progress-СУ Hatch Leak Check Public Affairs Office (PAO) Event in High Definition (HD) in Columbus Antibody Conjugates MELFI Sample Retrieve Antibody Conjugates Biocells Inoculation Deactivation of HDV Sony HVR-Z7E camcorder and closing of NASA MPEG-2 Viewer application Changeout of Dust Filter ПФ1-4 Cartridges in SM (ФГБ1ПГО_2_224_1, bag 432-7 (00069509R). Discard the removed items. Reflect changes in IMS) Antibody Conjugates Session Cleanup Rodent Research Access Unit Clean Environmental Health System (EHS) – Rad Detector Rotate On MCC Go Removal of Quick Release Screw Clamps (ЗВБ) Video Downlink via OCA Completed Task List Items None Ground Activities All activities were completed unless otherwise noted. JEMRMS Maneuver to transfer Handhold Exp Platform at SPB to JEMAL Three-Day Look Ahead: Thursday, 07/20: 66P undock, Antibody Conjugates Operations, JEM Airlock Operations, Russian EVA Tool Gathering Friday, 07/21: Node 2 Bacteria Filter R&R, CIR Rack Ops, Handheld External Platform Ops Saturday, 07/22: Crew off duty, housekeeping QUICK ISS Status – Environmental Control Group: Component Status Elektron Off Vozdukh Manual [СКВ] 1 – SM Air Conditioner System (“SKV1”) On [СКВ] 2 – SM Air Conditioner System (“SKV2”) Off Carbon Dioxide Removal Assembly (CDRA) Lab Standby Carbon Dioxide Removal Assembly (CDRA) Node 3 Operate Major Constituent Analyzer (MCA) Lab Idle Major Constituent Analyzer (MCA) Node 3 Operate Oxygen Generation Assembly (OGA) Standby Urine Processing Assembly (UPA) Standby Trace Contaminant Control System (TCCS) Lab Full up Trace Contaminant Control System (TCCS) Node 3 Off
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