Efficacy and Metabolism of Azonafide Antibody-Drug Conjugates in Microgravity (ADCs in Microgravity): With assistance from the Payload Developer, the crew viewed ADC cells with a microscope and fixated the BioCells. The crew also performed additional viewing of the cells with the microscope. The ADCs in Microgravity investigation evaluates new antibody-drug conjugates that combine an immune-activating drug with antibodies in order to target only cancer cells, increasing the effectiveness of chemotherapy and reducing its side effects. In microgravity, cancer cells grow in three-dimensional, spheroid structures that closely resemble their form in the human body, allowing for better drug testing. This investigation may accelerate development of targeted therapies for cancer patients. Meteor Hard Drive Swap: The crew performed a regular changeout of the Meteor hard drive located in the Window Observational Research Facility (WORF). The Meteor payload is a visible spectroscopy instrument with the primary purpose of observing meteors in Earth orbit. Meteor uses image analysis to provide information on the physical and chemical properties of the meteoroid dust, such as size, density, and chemical composition. Since the parent comets or asteroids for most of the meteor showers are identified, the study of the meteoroid dust on orbit provides information about the parent comets and asteroids. Waste and Hygiene Compartment (WHC) Pump Separator Replacement: On June 30th, the crew reported that the Pump Separator was making unusual noises and running longer after they shut off the urine valve. The Pump Separator had been installed since November 2016, past its expected life of ~180 days. Today the crew R&Rd the Pump Separator and the system is performing nominally. Cycle Ergometer with Vibration Isolation and Stabilization (CEVIS) Troubleshooting #3: On Saturday, the crew replaced the CEVIS Ergometer and Control Panel with “degraded” spares. This third round of troubleshooting was performed to determine if functionality still existed with Ergometer (S/N 1002) and Control Panel (S/N 1006). The crew had been using CEVIS with a Contingency Controller since June 3, 2017 and had recently reported that it had become cumbersome to use. CEVIS is currently functioning nominally utilizing the spares. Today’s Planned Activities All activities were completed unless otherwise noted. Regenerative Environmental Control and Life Support System (ECLSS) Recycle Tank Drain On MCC GO БМП Ф1 absorption cartridge regeneration; (init) FLUID SHIFTS [Deferred] Solution Crystallization Observation Facility (SCOF) Cable Connection Combustion Integrated Rack Alignment Guide Removal Advanced Resistive Exercise Device (ARED) Cylinder Flywheel Evacuation Regenerative Environmental Control and Life Support System (ECLSS) Recycle Tank Drain Part 2 Antibody Conjugates MELFI Sample Retrieve Antibody Conjugates Microscope Operations Environmental Health System (EHS) Total Organic Carbon Analyzer (TOCA) Water Recovery System (WRS) Sample Analysis SSC Auxiliary Laptop Computer System Virus Definition File Update Antibody Conjugates Biocells Fixation AQM Sieve Cartridge Remove and Replace Antibody Conjugates MELFI Sample Insertion Regenerative Environmental Control and Life Support System (RGN) Wastewater Storage Tank Assembly (WSTA) Fill Polar Hardware Install into Express Rack Commercial Generic Bioprocessing Apparatus 4, Unit Relocation Regenerative Environmental Control and Life Support System (RGN) Wastewater Storage Tank Assembly (WSTA) Fill Meteor Hard Drive Swap out Medical Laptop (MDLT) Relocate Environmental Health System (EHS) Total Organic Carbon Analyzer (TOCA) Sample Data Record XF305 Camcorder Setup Mouse Habitat Unit (MHU) Removal Antibody Conjugates Microscope Operations Evening Preparation Work Regenerative Environmental Control and Life Support System (ECLSS) Recycle Tank Fill Part 3 ABOUT GAGARIN FROM SPACE. Hardware Deactivation and closeout ops RADIOSKAF. ТПУ-120 small satellite battery setup and connection to HAM radio station power supply for recharge Environmental Health System (EHS) Total Organic Carbon Analyzer (TOCA) Waste Water Bag (WWB) Changeout Completed Task List Items Treadmill 2 System (T2) Monthly Inspection [Completed GMT 203] Crew Medical Officer (CMO) Proficiency Training [Completed GMT 203] Ground Activities All activities were completed unless otherwise noted. Nominal System Commanding Three-Day Look Ahead: Tuesday, 07/25: Fluid Shifts Chibis ops, Lighting Effects meter ops, RR habitat restock Wednesday, 07/26: T2 monthly inspection, ELF sample swap, ADC B cell fixation Thursday, 07/27: Spring VO2 ops, Capillary Structures, CBEF ops QUICK ISS Status – Environmental Control Group: Component Status Elektron Off Vozdukh Manual [СКВ] 1 – SM Air Conditioner System (“SKV1”) Off [СКВ] 2 – SM Air Conditioner System (“SKV2”) On Carbon Dioxide Removal Assembly (CDRA) Lab Operate Carbon Dioxide Removal Assembly (CDRA) Node 3 Standby Major Constituent Analyzer (MCA) Lab Idle Major Constituent Analyzer (MCA) Node 3 Operate Oxygen Generation Assembly (OGA) Standby Urine Processing Assembly (UPA) Standby Trace Contaminant Control System (TCCS) Lab Full up Trace Contaminant Control System (TCCS) Node 3 Off
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