Rodent Research-5 (RR-5) Systemic Therapy of NELL-1 for Osteoporosis: On Sunday the crew completed the first day of bone scans and sampling for RR-5. Later today they will perform the second set of scans and sampling operations. Because spaceflight has significant and rapid effects on the musculoskeletal system, it is important to investigate targeted therapies that could ameliorate some of the detrimental effects of spaceflight. The NELL-1 drug being studied in the RR-5 investigation has the potential to slow or reverse bone loss during spaceflight. Marrow: Over the weekend two crewmembers collected breath, air and blood samples for the Marrow investigation. They collected blood samples today as well. The blood samples are collected, processed in the centrifuge and placed in the Minus Eighty Degree Celsius Laboratory Freezer for ISS (MELFI). The Marrow investigation looks at the effect of microgravity on bone marrow. It is believed that microgravity, like long-duration bed rest on Earth, has a negative effect on the bone marrow and the blood cells that are produced in the bone marrow. Fine Motor Skills (FMS): On Saturday the crew completed a series of interactive tasks during a FMS session. The investigation studies how the fine motor skills are effected by long-term microgravity exposure, different phases of microgravity adaptation, and sensorimotor recovery after returning to Earth gravity. The goal of the investigation is to determine how fine motor performance in microgravity varies over the duration of six-month and year-long space missions; how fine motor performance on orbit compares with that of a closely matched participant on Earth; and how performance varies before and after gravitational transitions, including periods of early flight adaptation and very early/near immediate post-flight periods. Space Headaches: Over the weekend the 51S USOS crewmembers completed daily questionnaires for Space Headaches. They will complete additional questionnaires later today. The European Space Agency (ESA) Space Headaches investigation collects information that may help in the development of methods to alleviate associated symptoms and improvement in the well-being and performance of crewmembers in space. Headaches during space flight can negatively affect mental and physical capacities of crewmembers that can influence performance during a space mission. Sarcolab-3: The crew set up and configured the Muscle Atrophy Research & Exercise System (MARES) facility in the Columbus module for Sarcolab-3 operations. They installed the Ankle configuration and Electromyograph and Percutaneous Electrical Stimulation (PEMS) devices on MARES. The data collected for Sarcolab-3 will be compared to pre and post flight measurements to assess the impact of hypothesized microgravity induced muscle loss. Myotendinous and Neuromuscular Adaptation to Long-term Spaceflight (Sarcolab) investigates the adaptation and deterioration of the soleus, or calf muscle, where it joins the Achilles tendon, which links it to the heel and carries loads from the entire body. Muscle fiber samples are taken from crew members before and after flight, and analyzed for changes in structural and chemical properties. MRI and ultrasound tests and electrode stimulation are conducted to help assess muscle and tendon changes caused by microgravity exposure. Bigelow Expandable Activity Module (BEAM): The crew ingressed the BEAM, flipped the 10 mm thick Radiation Environment Monitor (REM) shield and photographed it. This REM Shield was previously printed on the 3D printer onboard the ISS and installed in the BEAM. BEAM is an experimental expandable module attached to the ISS. Expandable modules weigh less and take up less room on a rocket than a traditional module, while allowing additional space for living and working. They provide protection from solar and cosmic radiation, space debris, and other contaminants. Crews traveling to the moon, Mars, asteroids, or other destinations may be able to use them as habitable structures. Dose Distribution Inside the ISS – 3D (DOSIS 3D): The crew installed passive radiation detectors in the Columbus module in support of European Space Agency’s (ESA’s) DOSIS 3D investigation. Data from the various active and passive radiation detectors installed in the ISS are used in the determination of the radiation field parameters absorbed doses and dose equivalents inside the ISS. A concise three dimensional (3D) dose distribution map of all the segments of the ISS will be developed, based on this data and data from JAXA and NASA monitoring devices. Emergency Roles & Responsibilities Review: With the arrival of 51S, all crew members participated in this review. Items of discussion included crew accountability, access to escape vehicles and CDR responsibilities. Each crew member must be fully aware of procedure strategy and intent due to the complex nature of an emergency event. Today’s Planned Activities All activities were completed unless otherwise noted. ODF Books Update on iPAD Test video coverage for RT channel COSMOCARD. Preparation and start of a 24 h- long ECG recording Preparation of Reports for Roscosmos web site and social media ECON-M. Observation and photography Marrow Breath And Ambient Air Sample Collection МО-8. Configuration Setup Reminder 2 Marrow CSA Generic Frozen Blood Collection CSA Generic Frozen Blood Collection 25 Minutes – Subject Body Mass Measurement – BMMD CSA Generic Refrigerated Centrifuge Configure Handover SARCOLAB-3 day 1 reminder JEM Airlock Press МО-8. Closeout Ops CSA Generic Refrigerated Centrifuge Spin Conclude Handover CSA Generic Sample MELFI Insertion CSA Generic Frozen Blood Collection Conclude And Stow Handover Water Recovery System (WRS) Sample Analysis RADIOSKAF. Test checks of nanosatellites Water Recovery and Management Condensate Pump Gather JEM Airlock Leak Check Water Recovery and Management Condensate Pumping Init Combustion Integrated Rack Alignment Guide Removal Glacier Desiccant Swap SARCOLAB-3 Big Picture reading Deactivation of Soyuz 735 Gas Analyzer Procedures, preliminary EVA-43 timeline review, DVD viewingWater Recovery and Management Condensate Pumping Term ARED Handover Video Review MARES deployment Water Recovery and Management Condensate Pumping Restow In Flight Maintenance (IFM) Waste and Hygiene Compartment (WHC) Full Fill – Handover MARES Power On and Battery Charge MARES Ankle configuration installation Bringing ODF up to date using Soyuz 736 delivered files ISS Crew Adaptation Rodent Research Node 2 Camcorder Video Setup MARES Battery Charge Rodent Research 5 Dissection 2A Rodent Research 5 Dissection 2B Rodent Research Refrigerated Centrifuge Setup Test activation of Vozdukh Atmosphere Purification […]
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